The 355,000-square-foot facility, built entirely with American steel, serves as a massive expansion for the 500-acre campus. Inside, the hospital houses four dedicated heart operating rooms, a hybrid suite, and 10 interventional suites for cardiac catheterization and radiology. These spaces are supported by advanced equipment, including specialized imaging technology, heart-lung machines, and ECMO units for long-term cardiopulmonary support.
St. Luke’s Unveils $252 Million Heart Hospital in Bethlehem
A $252 million facility is set to open at St. Luke’s Anderson Campus this October, marking the largest construction project in the health network’s 150-year history. The five-story building adds 140 beds to the Bethlehem site, significantly expanding the region's capacity for complex cardiovascular care and specialized medical training.

Beyond clinical capacity, the project emphasizes staff efficiency and medical education. Designers integrated internal service corridors to streamline supply logistics, while the facility creates space for a new cardiac fellowship program. The expansion also benefits the broader Anderson Campus by adding a rooftop helipad and a larger cafeteria. This development continues a growth trend for the network, which has opened five full-service acute care hospitals in recent years, the highest volume of any system in Pennsylvania.




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